Neuroleptics Treatment of Tourette syndrome

space-filling representation of haloperidol molecule. haloperidol antipsychotic medication used treat severe cases of tourette s.

there no medications designed target tics. typical neuroleptics, or antipsychotics, used treat schizophrenia, one–pimozide (orap)–has been fda-approved treating tourette s. pimozide, along haloperidol , fluphenazine medications proven efficacy in controlling tics. these medications work blocking dopamine receptors, associated large side effect profile, including tardive dyskinesia, parkinsonism, dystonia, dyskinesia, , akathisia when used long-term.

atypical

atypical antipsychotics second generation, , serve alternative method of treating tics. these medications have more selective dopamine blocking effects, or block serotonin blocking of dopamine. medications in class used treat tics include risperidone, olanzapine, ziprasidone, quetiapine, clozapine, aripiprazole, tiapride, , sulpiride. atypical antipsychotics appear have lower risks of neurological side effects such tardive dyskinesia when used short-term, longer trials needed confirm this. of side effects associated these medications insomnia, weight gain, , school phobia. abnormalities in metabolism, cardiac conduction times, , increased risk of diabetes concerns these medications. there empirical support use of risperidone, , less support others.