α2-adrenergic receptor agonists Treatment of Tourette syndrome

clonidine (or clonidine patch) 1 of medications typically tried first when medication needed tourette s.

the α2-adrenergic receptor agonists (antihypertensive agents) show efficacy in reducing tics, other comorbid features of people tourette s. developed treat high blood pressure, these medications safer alternative neuroleptic medications people ts respond them. class of medication first tried tics, antihypertensives have lower side effect profile of medications more proven efficacy. evidence safety , efficacy not strong evidence of standard , atypical neuroleptics, there fair supportive evidence use, nonetheless. class of medication takes 6 weeks begin work on tics, sustained trials warranted. because of blood pressure effects, antihypertensive agents should not discontinued suddenly. clonidine (brand name catapres) works on tics half of people ts. maximal benefit may not achieved 4–6 months. small number of patients may worsen on clonidine. guanfacine (brand name tenex) antihypertensive used in treating ts. side effects can include sedation, dry mouth, fatigue, headaches , dizziness. sedation can problematic when treatment first initiated, may wear off patient adjusts medication.